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In ovariectomized rats, replacement of estradiol in this nucleus reduces food intake and this effect is blunted by co-administration of an ER antagonist (137, 138)

[DOI] [PubMed] [Google Scholar] 109.Pop VJ, de Vries E, van Baar AL, et al

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Approved GLP-RAs In 2005, Exendin-4 (Exenatide/ BYETTA), the world's first GLP-1RA, was approved by the FDA for the adjuvant treatment of type 2 diabetes with two injections per day (BID)